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Symptoms range from those of alcoholic hepatitis to the complications of end-stage liver disease, such as portal hypertension (often with esophageal varices and upper gastrointestinal bleeding, splenomegaly, ascites, and portosystemic encephalopathy)

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doi:10.1016/j.pneurobio.2014.11.004 Evidence-Base Disclosure The published evidence base for Dihexa consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments

Many factors are thought to impact on the functioning of this enzyme including physiological status including hormones (7) and gastrointestinal diseases (8), medications (9) and genetics (2)

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Besides, CCM therapy stimulates detoxification enzymes due to free radical scavenging and lysosomal release inhibition (Manikandan et al