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At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) (Judson et al., 2011) reveals a similar temporal expression pattern of MET as in rodents, with peak levels corresponding to the same periods detected in mice and rats

So, where does the difference come from

Which analytical documents are available

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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines, but no NNMT inhibitor has reached regulatory approval to date