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Current HDAC inhibitors generally target the conserved catalytic pocket shared by zinc-dependent HDACs, resulting in limited isoform selectivity [33, 35]

It also supports the synthesis of serotonin, GABA, and dopamine which is why B6 status directly affects mood, sleep, and anxiety [13]

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Insulin triggers farnesyltransferase activity in adipocytes, leading to p21Ras modification and subsequent Mitogen-activated protein kinase (MAPK) pathway activation - a crucial sequence for metabolic signaling (193)

Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake

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