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Nature New Biology

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151,157 Bid knockout using CRISPR/Cas9 approaches can protect neurons against both ferroptosis and oxytosis

Okcu MF, Wang RY, Bueso-Ramos C, Schober W, Weidner D, Andrassy R, Blakely M, Russell H, Ozkan A, Kuttesch J, Andreeff M , Chan KW, Ater J

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The consequent ROS accumulation in the body is inevitably associated with tissue injury [1], since ROS are known to damage cell components, particularly DNA, leading to loss of function, induction of apoptosis, or even carcinogenesis [2]