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Miao X, Alidadipour A, Saed V, Sayyadi F, Jadidi Y, Davoudi M, Amraee F, Jadidi N, Afrisham R

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Following injury, macrophages and other innate immune cells rapidly infiltrate the wound site, secreting pro-inflammatory cytokines such as TNF-, IL-1 and chemokines that orchestrate early inflammatory responses and influence both pain and healing processes [41,42]

Several mechanisms within the TME have been implicated in the resistance to anti-PD therapy, such as loss of neoantigens and low expression of PD-L1 [5]

In this review, we will describe the biological and biochemical mechanisms of action of ozone therapy with the aim of evaluating both positive and critical aspects of ozone use as a therapeutic adjuvant in the light of emerging viral infections, such as SARS-CoV-2 and microbiome-associated disorders related to SARS-CoV-2

Interestingly, LDHB KD led to increased cystine (CysSS) but decreased GSH disulfide (GSSG