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Further research is needed to elucidate potential mechanisms related to L-citrulline supplementation in other aspects of performance. Source : Journal of the International Society of Sports Nutrition Published online 2023 Apr

Genes Chromosomes Cancer 18 : 286291 Yao KS, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC (1995) Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines

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EGFR also induces ERK2 to phosphorylate PKM2 at Ser 37, which allows peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) to bind to PKM2, prompting PKM2 to translocate to the nucleus, upregulating lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1) expression and promoting the Warburg effect (Yang et al., 2012b)