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And they hit your gastrointestinal system hard if you start at a full therapeutic dose without giving your body time to adapt

Thats roughly 3% of the population

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GLP-1 agonists can restore spontaneous ovulation in women with insulin-resistant PCOS by correcting the hyperinsulinemic environment that suppresses normal follicle development

This is most relevant for weight-based peptides like kisspeptin (dosed in mcg/kg) and less relevant for receptor-saturating peptides like BPC-157, where tissue concentration at the injury site matters more than total body distribution

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