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Understanding how pharmacological and microbiota-targeted interventions converge on shared signaling pathways may therefore be critical for identifying biomarkers of treatment response and developing more effective, mechanism-based therapeutic strategies

Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia

This makes it distinct in research examining endogenous sleep regulation mechanisms rather than pharmacological sleep induction

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Cells 10 , (2021)