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Surprisingly, FRA prevalence was very high in children with ASD, and the response to leucovorin in children was rated by parents as favorable on several cognitive dimensions
Deficiency of lysosomal acid phosphatase

Plant Physiol Biochem 167:257268

10.1016/s0254-6272(13)60130-2 153 WangR.ChenY.WangZ.CaoB.DuJ.DengT.et al (2023)

Have they always been there, or did they appear over time

In a cross-sectional study of 139 men and women aged 60 years in Australia, copper concentrations and copper/zinc ratios were found to be negatively associated with depressive symptoms (Mravunac et al., 2019)
