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In terms of redox control, reduction of the Cys186-Cys406 disulfide bridge considerably decreases protein activity (Hicks et al., 2007
Response to:Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation by Ciccia et al

While not confirmed by specific neuronal markers, the selectivity of staining is indicative of neuronal expression, a conclusion confirmed by immunostaining of mouse periventricular neurons 43

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