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doi: 10.1038/nrendo.2011.77

The lack of a band at the expected location of the gradient indicates that the 150S particles made under these conditions are unstable and fall apart, probably during our purification procedure that includes a strong detergent, SDS

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If macrophages are depleted with clodronate liposomes the blood-myenteric barrier remains intact, indicating that in a proinflammatory setting macrophage activation is deleterious to the integrity of the ENS

this presumably is functions as a detoxification mechanism