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All three mammalian Nei-like DNA glycosylases demonstrate an unusual preference for single-stranded DNA substrates and other open DNA conformations such as bubbles, loops, and recessed DNA duplexes generated during DNA replication and transcription

22 Entacapone is commonly used in clinical practice and, by adding entacapone to the LD-CD intestinal gel, the sponsors are aiming to explore whether TriGel has an advantage over LD-CD intrajejunal infusion in terms of longer benefit per day and potentially reducing the cost