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At its core, aging involves the accumulation of cellular damage over time

The concentration that inhibits 50% of the binding of angiotensin II (IC 50 ) is 20 nM [1]

Intracellularly, ROS are principally generated by mitochondrial respiration and redox enzymes, such as uncoupled nitric oxide synthase, cytochrome P-450 isoforms, and NADPH oxidase subtypes (NOXs), in the form of superoxide (Fig