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It also modulates oxidative stress via the nuclear factor 2 related to erythroid 2 (Nrf2) pathway, a transcription factor that controls the expression of numerous cytoprotective and antioxidant genes

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Functional experiments of HCC cell lines with SLC25A39 knockdown were conducted in vitro (cell proliferation, Transwell migration and invasion, and apoptosis assays) and in vivo (xenograft experiments)