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But a study of 124 patients who had taken 24 doses of natalizumab observed no rebound activity (Clerico et al ., 2014), suggesting that longer treatment with natalizumab may decrease the risk of rebound

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The drug can be administered orally, sublingually, by intramuscular injection, subcutaneous injection, or by intravenous infusion with a gradually increasing flow, until the intended target dose is achieved (Figure 5) [112]

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