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J Soc Gynecol Investig

Six-hour incubation of human RBCs with 15 mM DEET resulted in slight lytic cell death at concentrations of 4 and 5 mM and significantly increased Annexin V FITC and Fluo3 fluorescence, with reduced FSC observed at 5 mM [436]

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Also, with the current high level of concern about possible skin damage from sun exposure, many people cover up or use so much sunscreen that the sun cannot access their skin to make vitamin D3