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To view a copy of this licence, visit About this article Cite this article Ruggeri, R.M., Virili, C., Mocini, E

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The MAPK/ERK signaling cascade primarily mediates cellular proliferation, while the PI3K/AKT pathway predominantly regulates cell survival and apoptosis (Macvanin et al., 2023

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Moreover, using probucol (500 mg/day, P.O for 6 months) for secondary prevention in patients with CHD lowered the incidence of the patients primary endpoint (cardiovascular disease death, hospitalization rate), which may be partly due to its strong antioxidant capacity [245]

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The remaining 304 articles were removed for the following reasons: they did not focus on the 677C allele of the MTHFR gene

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S-Methylglutathione, which is lacking the free thiol group present in glutathione, stimulates neither the nonenzymatic nor the GST-catalyzed isomerization, but inhibits the glutathione-independent GST catalysis (Pettersson and Mannervik, 2001)

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Regarding the kidney tissues, the epithelial cells of renal tubules showed vacuolar degeneration, damaged brush borders, and the presence of protein casts in the LPS group, unlike in the control group (Figure 3B)

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