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Timeline of Changes 12 weeks post-treatment Muscle activity begins to weaken Early reduction in masseter volume Subtle changes in jawline support 26 months post-treatment Continued muscle atrophy Skin adapts to reduced support In at-risk patients, tissue may descend, appearing as jowls Because muscle reduction happens gradually, jowls often appear months later , making the connection less obvious to patients

Flow of the study protocol for inclusion and data and sample collection, LEPJAR-NC study, New Caledonia, 20212024

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Weiss LC, Leimann J, Tollrian R (2015a) Predator-induced defenses in Daphnia longicephala: location of kairomone receptors and timeline of sensitive phases to trait formation