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(2) Whitening skin
This enzymatic defect reduces synthesis of glutathione and the resulting low intracellular glutathione levels remove the normal tonic inhibition of the enzyme -glutamylcysteine synthetase (Figure 1 and Figure 2, reaction 4)

[DOI] [Google Scholar] Chen J., Zhang L., Yang F., Yi J., Yang Z., Li Z., et al
Cortical dysfunction in non-demented Parkinsons disease patients: a combined (31)P-MRS and (18)FDG-PET study
Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway

The causes can be broadly categorised into exogenous (external) and endogenous (internal) factors, with the latter being of greater clinical significance
