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Experiments in vitro have demonstrated that mechanical stress triggers [Ca2+]i elevations in retinal ganglion cells, microvascular endothelial cells, nonpigmented cells of the ciliary body, glia and the trabecular meshwork (51, 113, 118-120) whereas Ca2+ removal from the external medium or calcium chelation block stretch- and swelling-induced Ca2+ influx and stretch-induced remodeling of the cytoskeleton

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Additionally, Dihexa has been shown to increase the production of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), which play a crucial role in promoting neuronal survival and growth
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