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Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

Thus, associations of serum TGs with liver cirrhosis may be affected by sex

There is a significantly lower prevalence in Africa[8, 7, 9], while North America is split with HCV-3 representing only 1012% of all chronic HCV infection (CHC) infection in the United States, while accounting for 22% in Canada

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Drug Alcohol Rev

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