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Mechanistically, p53 induces ferroptosis by directly inhibiting SLC7A11 via system Xc(-) or by upregulating recombinant spermidine/spermine N1-acetyltransferase 1 (SAT1) downstream of p53, which is involved in polyamine metabolism (23)

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NAC FOR CONTRAST-INDUCED NEPHROPATHY The intravascular administration of contrast media for radiologic imaging techniques can result in acute renal dysfunction [176]

However, it should be noted that these 2 modelsER and aromatase deficiencyalso exhibit a marked increase in serum T levels that acts as a confounding factor

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Lichvarova L, Henzi T, Safiulina D, Kaasik A, Schwaller B