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Associations with metabolic diseases In addition to the neuropsychiatric effects and inherited disorders described above, dysregulated Mn homeostasis has been implicated in a wide range of human pathologies

Persistent TNF- action has been related to the generation of oxidative stress and tissue remodelling, thereby relating COPD pathogenesis to the extremes of the innate immune system [18]
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doi: 10.1111/j.1469-7793.1998.577bn.x

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