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Some drugs, including proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) are acid-inhibiting, impairing the release of dietary B12 from food proteins, thus producing risk of B12 deficiency (Lam et al., 2013)

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Optimal Timing for Taking Vitamin B12 Supplements For individuals who require vitamin B12 supplementationwhether due to confirmed deficiency, dietary restrictions (such as veganism), or malabsorption conditions the timing of supplementation is generally flexible and should be guided by personal preference and tolerability rather than any specific metabolic advantage related to weight loss

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