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The endocannabinoid system in human keratinocytes

Under physiological conditions, the cytoplasmic protein Kelch-like ECH-associated protein 1 (Keap1), an adapter protein of Cullin-3-based ubiquitin ligase, binds to NRF2 to suppress NRF2 activation by mediating its ubiquitination and degradation (Fig

This effect is primarily due to its flavonoid structure, consisting of a 2,3 double bond in combination with a 4-oxo bond in the C ring, which is remarkably efficient at scavenging free radicals

Roland-Zejly L, Moisan V, St-Pierre I, et al

Finally, it is widely accepted that GH/IGF-1 are involved in cell senescence and apoptosis
