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Due to their poisonous, carcinogenic, and mutagenic properties, and their pervasive production, recalcitrance, as well as environmental persistence, PAHs, heavy metals, and PAM have tremendous public interest and crucial environmental problems across the globe

(230) conveyed that the levels of the soluble form of TLR-2 are increased in the serum of individuals with MS, suggesting a potential novel biomarker for the disease

However, the SASP factors secreted by senescent cells induce CD38 expression and increase CD38-NADase activity in non-senescent immune cells and endothelial cells 27

In accordance to the activation of HIF-1 (Figure 5A), roxadustat significantly increased the PFKFB3 expression on mRNA and protein level in a dose-dependent manner in both neurons and astrocytes (Figure 8B)

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274 , L134L142 (1998)