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Despite improvements in macroscopic circulation, epinephrine may contribute to a microvascular paradox , whereby cerebral microcirculatory blood flow is reduced despite increased systemic perfusion

In another study, a clear dose-response relationship was identified between daily use of APAP and increased asthma morbidity ( While there have been many proposed mechanisms, the exact mechanism of action of APAP remains unclear

10.1016/j.scispo.2018.02.006 172 ZhouQ.ZhuX.-J.LiJ.-H

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[DOI] [PubMed] [Google Scholar] 29.Di Renzo MF, Olivero M, Martone T, Maffe A, Maggiora P, Stefani AD, et al

doi: 10.1038/s41574-018-0087-0