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However, the health-beneficial effects of lignin-derived macromolecules are still far less investigated than that of tannins as a phyto-macromolecule, either in vitro assays or as animal feed supplements ( Lignin-Based Polymers/Lignophenols Lignophenols (LPs) are lignin-derived macromolecules produced experimentally from raw biomass by phase-separation systems, in which cellulose and hemicellulose of lignocellulosic are converted into hydrolyzed carbohydrates while lignin is converted into LPs (Sato et al., 2006