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Similarly, AAV-mediated overexpression of IGFBP2 in skeletal muscle reduced muscle mass and induced a slower muscle phenotype [107]

After Prx reduces its target, Trx recycles the oxidized form of Prx back to its reduced state ( The TXN2 gene encodes thioredoxin-2, that reduces Prx dimers that are formed upon reaction with H 2 O 2 , thereby keeping Prx in their reduced and active state (Supplementary Figure S3)

A principal mechanism of action involves the modulation of gene and protein expression governing tight-junction signaling pathways within intestinal IECs, thereby influencing barrier assembly, permeability, and overall epithelial integrity ( For instance, studies demonstrated that L

and (3) Lungs/ Gastrointestinal tract-bloodbrain