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For the Greeks and Romans, their solution was that tragedy occurred because the gods were at best indifferent to mankind, at worst downright cruel

Once nAbs did emerge in this group, the responses targeted epitopes known to be involved in CD81 binding, and rapidly drove a decrease in binding efficiency, likely as a result of the emergence of immune escape mutations

Ma J, Trinh RT, Mahant ID, Peng B, Matthias P, Heijnen CJ, et al

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Ascorbate oxidising and recycling enzymes 8.1

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