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No serious adverse events, liver enzyme elevations, or cardiovascular changes were documented in the Phase 1 safety study published in the Journal of Clinical Endocrinology & Metabolism in 2024

Less commonly, more serious complications can arise, including: an abscess, or collection of pus tissue necrosis, or tissue death granuloma, or inflammation in the tissue muscle fibrosis, or scarring of muscle tissue hematoma, where blood seeps out of blood vessels into the surrounding tissue injury to blood vessels and nerves People who notice the following symptoms should call a doctor immediately: severe pain at the injection site prolonged or excessive bleeding tingling or numbness around the muscle redness, swelling, or warmth at the injection site drainage at the injection site signs of an allergic reaction, such as swelling or breathing problems Intramuscular injections are a common and effective way to deliver medication

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(Refer to page 279 for kilogram-to-pound conversions and page 13 for rounding instructions.) Step 2 Calculate the safe dose range (SDR) using a calculator and current safe dose recommendations found in the drug literature or drug handbook for this weight child in mg per kg or mcg per kg