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JPEN J Parenter Enteral Nutr

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Ferroptosis agonists directly or indirectly affect glutathione peroxidase (GPXs) through various pathways, leading to a reduction in antioxidant capacity, accumulation of ROS, and ultimately oxidative cell death (115, 116)

Low-molecular-weight antioxidants, such as ascorbate, glutathione, and urate, present in the lung epithelial lining fluid and tissue, remove Cl(2) and HOCl and thus decrease injury to critical target biological targets

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In this study, Sc GSH1, Sc GSH2, and St GshF were heterologously expressed in Pichia pastoris GS115 to realize the dual-path synthesis of GSH in yeast