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Moving forward, mechanistic in vivo toxicity studies must be prioritized to clarify hazard pathways and establish safety thresholds for BSPs clinical translation

2021;82:S109S126

A previous study on a rat stroke model where focal cerebral ischemia was produced by middle cerebral artery occlusion and pretreated with NAC at150 mg/kg, showed a 49.7% reduction in brain infarct volume and 50% reduction in the neurological evaluation score compared to untreated animals 5

Protein and PeptideBased Nanoparticles Protein and peptide utilize amino acids as fundamental building blocks

10.1677/JOE-10-0217 J

2 2.8.3 Widely targeted metabolomics analysis Frozen tissue specimens were homogenized and extracted using ice-cold methanol:water (7:3, v/v) supplemented with isotope-labeled internal standards,followed by multi-platform LC-MS/MS analysis