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The global DNA methylation in the livers of HFD-fed mice was increased, with significant gene-specific hypermethylation of CYP2R1, CYP27A1, CYP27B1, and VDR, and hypomethylation of CYP24A1

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In some cases, these variations may be mild and temporary, but in others, they can be a sign of a more serious underlying medical condition

The interaction isnt universal toxicity but pathway interference at concentrations that individual compound safety profiles dont predict

[DOI] [PubMed] [Google Scholar] Shikanai T, Takeda T, Yamauchi H, Sano S, Tomizawa K, Yokota A, Shigeoka S

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