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The concept of intrinsic versus extrinsic apoptosis

Bone: aids mineralization with calcium and vitamin D

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However, the level of oxygen that cells are exposed to is known to be able to impact biochemical reactions and cellular activities, especially energy metabolism and ROS production

The authors sincerely thank Professor Graham Rook (University College London, United Kingdom) for discussions on his Old Friends Hypothesis and critical reading of the manuscript, and Professor Hanna Kmita (Adam Mickiewicz University, Poznan, Poland) for a critical reading of the manuscript and helpful suggestions for its improvement

These pathways include anti-apoptotic proteins, metabolic regulators, and inflammatory mediators, as illustrated in Figure 2 below