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Means and Anderson, 1983)

Resistance to osimertinib, a third-generation tyrosine kinase inhibitor targeting EGF receptor used as first-line therapy for patients with non-small cell lung cancer (NSCLC) harboring mutant EGFR, is mediated by IGF-1R signaling activated by IGF-2 in NSCLC cell lines (41)

Additionally, in vitro studies with pituitary cells suggest a similar increase in GH release upon exposure to DSIP, albeit with a notable decline at higher concentrations

Infect Immun (2001) 69(6):403440

It is known for its smaller molecular size, which enables better absorption by the skin

It is also noteworthy that many contemporary probiotic strains are genetically engineered in laboratory settings to enhance their beneficial properties
