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doi: 10.1016/0303-7207(91)90137-H

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116 SIRT1, a key molecular regulator at the crossroads of metabolic and immune pathways, modulates immune cell function through deacetylation, affecting inflammation, autophagy, and oxidative stress responses, thereby maintaining hepatic immune homeostasis

Bagwell, C

The co-crystallized fragments found in sub-pockets A-C and the protein were used as input for the SZMAP, Gameplan, and vBrood applications and visualization in MOE

On the other hand, polyubiquitination of the voltage-dependent anion channel 1 (VDAC1) by Parkin recruits the ubiquitin binding protein p62 that also interacts with the autophagosomal protein LC3/GABARAP (Figure 4.3)