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In mouse renal tissue, the secreted glycoprotein progranulin (PGRN) induces mitobiogenesis and mitophagy through the PGRN-Sirt1-PGC-1/FoxO1 signaling axis, reducing the effects of excessive hyperglycemia on mitochondrial dysfunction [213]

Tesamorelin (a GHRH analog) targets visceral fat through the GH/IGF-1 axis

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Zhang, Q