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25 The body's antioxidant defenses weaken with age, reducing their capacity to counteract ROS

The above is usually talked of in terms of 'anaemia', but it does show that there is a complicated link between B12, B6, folic acid, zinc and vitamin D levels, chronic disease (anaemia of chronic disease) and how the body 'manages' serum iron, ferritin, and transferrin iron saturation and keeps these in balance (or not, as in your case)

Zundel MT , Feih JT , Rinka JR , et al

Xue S, Chen S, Ge Y, Guan T, Han Y

The decrease in GSH in the endothelium induces ROS levels, decreases the activity of eNOS, and increases organ fibrosis [138]

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