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doi: 10.1038/ncomms2478

G., Zupkas, P
p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation

Epionce has been granted 20 US patents and is proven safe and effective by over 15 independent (NOT bought and paid for)clinical trials

Once in the body, creatine is primarily taken up by muscle tissue, with approximately 1-2% per day non-enzymatically converting to creatinine, which is then excreted by the kidneys

Symptom documentation supports medical necessity for treatment