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It is postulated that clinical symptoms, including CNS complications such as convulsion, coma and lethargy, may be triggered by the accumulation of metabolites and their acyl-CoA derivatives that disrupt intermediary metabolism [6669]

J Mol Med (berl) 93(12):12871296

[2][10][11] However, there were some mild side effects, including nausea and stomach upset

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Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects