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Ample genetic evidence proves Mc4r signaling to be a critical component of the body-weight regulation system

Several neurotransmitters (serotonin, noradrenaline, dopamine, and histamine), peptides (neuromedin U, urocortin, bombesin, amylin, galanin), hormones (thyroid hormone, growth hormone) and cytokines (ciliary neurotrophic factor) also play a role in modulating feeding behavior and energy expenditure [5-10]

This is due to several biological factors, including lower total body water, differences in alcohol dehydrogenase (ADH) activity, and hormonal influences 18

10.1038/nature14344 57 JiangX.StockwellB

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In vitro and in vivo treatment of JMF4073 eliminates WT-Bcr-Abl-32D CML cells