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Moreover, in contrast to rat kidney mitochondria, the import of GSH in rat liver mitochondria showed both a high affinity and low affinity transport component (Martensson et al., 1990)

Research has shown that IGF1 LR3 can synergize with other growth factors such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) to enhance cellular responses

Hence, the function of Gln metabolism in diverse cancer types, cell types, and individual cancer cases should be further explored to optimize the efficacy of Gln-targeted therapies in oncology

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This scenario could potentially lead to chemoresistance, diminishing the effectiveness of conventional cancer treatments

Witschi, A., et al., The systemic availability of oral glutathione
