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While all polyphenols are good for you, the ones found in the grape seed are a specific type known as oligomeric proanthocyanidins, or just proanthocyanidins for short, and these have unique benefits

Maiti A, Cortes JE, Patel KP, Masarova L, Borthakur G , Ravandi F, Verstovsek S, Ferrajoli A, Estrov Z, Garcia-Manero G, Kadia TM, Nogueras-Gonzlez GM, Skinner J, Poku R, DellaSala S, Luthra R, Jabbour EJ, O'Brien S, Kantarjian HM

Ben Rejeb et al., 1981) attributed ROS detoxification in chloroplast to the ascorbate-glutathione system

Toxicology of melatonin

Please keep in mind that while experimenting with dosage can be helpful, theres no substitute for professional advice

A., Munshi, C., Lee, H