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These data suggest that the genetic imbalance observed in DS leads to greater instability in transcriptional control (454, 455)

doi: 10.1038/s41573-021-00233-1

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Conclusions In summary, this study provides comprehensive mechanistic insights into how Retatrutide, a triple agonist of the GIP, GLP-1, and glucagon receptors, exerts potent anti-obesity and metabolic benefits through coordinated molecular and metabolic remodeling of adipose tissue

Tsunoda S, Kimura N, Fujii J