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A downregulation of FTO expression leads to an abnormal increase in m6A levels, impairing ovarian function and ultimately resulting in premature ovarian failure [82]

and 2) significant improvements in the accuracy of imaging studies such as ultrasound over time

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doi: 10.1371/journal.pone.0090533 163 GhramhHAIbrahimEHKilanyM

This establishes an interaction in which rising hCG causes TSH to diminish, which can lead to gestational thyrotoxicosis (Roti et al., 1981)