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Representative polysaccharides from microorganisms with antioxidation and anti-diabetic effects show in Table 3

It may support telomere elongation, regulate circadian rhythms via the pineal gland, and promote healthy cell cycle activity, offering potential anti-aging benefits in vitro and experimental studies

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Data availability The complete data and code for this study are available at Abbreviations BCFAs: Branched-chain fatty acids CPM: Copies per million FFQ: Food-frequency questionnaire GLMM: Generalized linear mixed regression model IGC: Integrated gene catalog KO: KEGG orthologue LAB: Lactic acid-producing bacteria SCFAs: Short-chain fatty acids TPM: Transcripsper million UHPLC/MS/MS: Ultra-high-performance liquid chromatography/tandem accurate mass spectrometry UMAP: Uniform Manifold Approximation and Projection References Gill SR, Pop M, DeBoy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, et al

Importantly, this work also revealed the synaptic and behavioral abnormalities in these models of ASD [172, 173, 175] that were reversed by the selective nNOS inhibitor 7-nitroindasole [172, 173]

Maddrey WC, Boitnott JK