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TB-500 works systemically and thus does not need to be administered to a specific target

Dysregulation of systemic circadian rhythms (e.g., sleepwake cycle), melatonin activity, and secretion are common symptoms of dementia in AD [95]

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The worldwide challenge of the dementias: a role for B vitamins and homocysteine

doi: 10.1007/978-3-030-54719-6_3 222 TwaijB.HasanM

Enzymatic control of cysteinyl thiol switches in proteins
