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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Kaur 2009

Wolpert et al., 2020)

Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study

Food Chemistry, 348 , Article 129150

Patients should promptly report any adverse reactions or discomfort following an injection using bacteriostatic water
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