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Factors that should prompt investigation for melanoma include linear band widths greater than 3 mm, linear bands wider proximally than distally, heterogeneous nail discoloration, irregular border of the discloration, nail plate dystrophy or ulceration and bleeding, or involvement of high-risk digits (ie, thumb, index finger, great toe)

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Up to 60% of patients who take PDE5-Is as first line on-demand treatment show a good response, defined as erection with sufficient rigidity for penetration [17, 19]

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10.1007/s13679-025-00630-2 191